In the early nineteenth century, Spanish power went into rapid decline. Although Spain was allied with France during the Napoleonic Wars, in 1808 Napoleon Bonaparte forced the Spanish king to abdicate and put a Bonaparte on the Spanish throne. In response, Spanish people erupted in revolt in Madrid and throughout Spain, setting off a chain of uprisings in Latin America. In Honduras, resentment against rule by the exiled Spanish king increased rapidly, especially because increased taxes for Spain's struggle against the French threatened the cattle industry. In 1812 disturbances that broke out in Tegucigalpa were more linked to long-standing rivalry with Comayagua, however, than to opposition to Spanish rule. The disturbances were quickly controlled, and, to appease local discontent, the municipal government of Tegucigalpa was reestablished.

The rivalry between Tegucigalpa and Comayagua helped precipitate the final collapse of Spanish authority in Honduras. A new Spanish administration attempted to transfer Comayagua's tobacco factory to Tegucigalpa. This move led to defiance by Comayagua, which refused to acknowledge the authority of the government in Guatemala. The weakened Spanish government was unable to end Comayagua's defiance, and for a time civil strife threatened to break out. Conflict was averted by the decision made by all the Central American provinces on September 15, 1821, to declare their independence from Spain. This action failed to resolve the dispute between Tegucigalpa and Comayagua, however; the former now urged the creation of a unified Central American state, while the latter favored union with the Empire of Mexico under the rule of General Augustín de Iturbide. Ultimately, Comayagua's position prevailed, and in early 1822 the Central American provinces declared their allegiance to Mexico.

This union lasted just over a year and produced few if any benefits for either party. In March 1823, Iturbide was overthrown in Mexico, and the empire was replaced by a republic. The Central American Congress, in which Comayagua but not Tegucigalpa was represented, was quickly convened. With little debate, the United Provinces of Central America declared their independence from Mexico. Mexico's only effort to reverse this decision consisted in maintaining control over Chiapas, the northernmost of the six previous provinces of Central America.

Data as of December 1993