Because the Turkmen generally were indifferent to the advent of Soviet rule in 1917, little revolutionary activity occurred in the region in the years that followed. However, the years immediately preceding the revolution had been marked by sporadic Turkmen uprisings against Russian rule, most prominently the anti-tsarist revolt of 1916 that swept through the whole of Turkestan. Their armed resistance to Soviet rule was part of the larger Basmachi Rebellion throughout Central Asia from the 1920s into the early 1930s. Although Soviet sources describe this struggle as a minor chapter in the republic's history, it is clear that opposition was fierce and resulted in the death of large numbers of Turkmen.

In October 1924, when Central Asia was divided into distinct political entities, the Trans-Caspian District and Turkmen Oblast of the Turkestan Autonomous Soviet Socialist Republic became the Turkmen Soviet Socialist Republic. During the forced collectivization and other extreme socioeconomic changes of the first decades of Soviet rule, pastoral nomadism ceased to be an economic alternative in Turkmenistan, and by the late 1930s the majority of Turkmen had become sedentary. Efforts by the Soviet state to undermine the traditional Turkmen way of life resulted in significant changes in familial and political relationships, religious and cultural observances, and intellectual developments. Significant numbers of Russians and other Slavs, as well as groups from various nationalities mainly from the Caucasus, migrated to urban areas. Modest industrial capabilities were developed, and limited exploitation of Turkmenistan's natural resources was initiated.

Data as of March 1996